Helicobacter pylori infection has been associated with chronic atrophic gastritis, a precursor of gastric cancer.
We conducted a prospective, case-controlled study to investigate whether H. pylori infection increases the risk of gastric cancer in Korean people with a high risk of gastric cancer.
We enrolled 160 gastric cancer patients who were confirmed by endoscopic biopsy during 1994 and 160 age-matched control subjects with non-ulcer dyspepsia were compared to document the relationship between H. pylori infection and gastric cancer.
The presence of H. pylori infection was determined by the rapid urease test and/or histology by Wright-Giemsa staining.
The overall presence of H. pylori infection was 60% in gastric cancer patients and 51.9% in age-matched control subjects (odds ratio 1.39 ; 95%, confidence interval 0.894-2.17 ; P=0.143).
Carcinomas of cardia, body and antrum were not associated with H. pylori infection (odds ratio 1.43,1.69 and 1.29, respectively ; 95% confidence interval, 0.271-7.52,0.787-3.62 and 0.689-2.43, respectively ; P=0.178,0.177 and 0.642, respectively) nor was the intestinal or diffuse type of cancer (odds ratio 1.39 and 1.40, respectively ; 95% confidence interval 0.791-2.45 and 0.681-2.87, respectively ; P=0.250 and 0.835, respectively).
Gender was not a risk for gastric cancer.
In contrast to previous studies, these results do not provide evidence of H. pylori infection for gastric carcinogenesis in Korea.
Mots-clés Pascal : Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Facteur risque, Transformation maligne, Carcinome, Estomac, Epidémiologie, Homme, Corée, Asie, Appareil digestif pathologie, Estomac pathologie, Tumeur maligne
Mots-clés Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Risk factor, Malignant transformation, Carcinoma, Stomach, Epidemiology, Human, Korea, Asia, Digestive diseases, Gastric disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0187522
Code Inist : 002B05B02F. Création : 21/05/1997.