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  1. Helicobacter pylori infection and the risk of gastric cancer among the Korean population.

    Article - En anglais

    Helicobacter pylori infection has been associated with chronic atrophic gastritis, a precursor of gastric cancer.

    We conducted a prospective, case-controlled study to investigate whether H. pylori infection increases the risk of gastric cancer in Korean people with a high risk of gastric cancer.

    We enrolled 160 gastric cancer patients who were confirmed by endoscopic biopsy during 1994 and 160 age-matched control subjects with non-ulcer dyspepsia were compared to document the relationship between H. pylori infection and gastric cancer.

    The presence of H. pylori infection was determined by the rapid urease test and/or histology by Wright-Giemsa staining.

    The overall presence of H. pylori infection was 60% in gastric cancer patients and 51.9% in age-matched control subjects (odds ratio 1.39 ; 95%, confidence interval 0.894-2.17 ; P=0.143).

    Carcinomas of cardia, body and antrum were not associated with H. pylori infection (odds ratio 1.43,1.69 and 1.29, respectively ; 95% confidence interval, 0.271-7.52,0.787-3.62 and 0.689-2.43, respectively ; P=0.178,0.177 and 0.642, respectively) nor was the intestinal or diffuse type of cancer (odds ratio 1.39 and 1.40, respectively ; 95% confidence interval 0.791-2.45 and 0.681-2.87, respectively ; P=0.250 and 0.835, respectively).

    Gender was not a risk for gastric cancer.

    In contrast to previous studies, these results do not provide evidence of H. pylori infection for gastric carcinogenesis in Korea.

    Mots-clés Pascal : Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Facteur risque, Transformation maligne, Carcinome, Estomac, Epidémiologie, Homme, Corée, Asie, Appareil digestif pathologie, Estomac pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Risk factor, Malignant transformation, Carcinoma, Stomach, Epidemiology, Human, Korea, Asia, Digestive diseases, Gastric disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0187522

    Code Inist : 002B05B02F. Création : 21/05/1997.