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  1. The incidence of adenocarcinoma in Barrett's esophagus : A prospective study of 170 patients followed 4.8 years.

    Article - En anglais

    Objectives 

    Barrett's esophagus is a premalignant condition defined by the presence of intestinal metaplasia in the esophagus.

    Estimates of the incidence of adenocarcinoma developing in patients with Barrett's esophagus vary widely.

    We prospectively followed a cohort of patients to define the incidence.

    Methods 

    Between January 1982 and April 1995, all patients undergoing upper endoscopy at the VA Medical Center in Tucson, AZ, were surveyed for Barrett's esophagus.

    One hundred seventy-seven patients (174 males, three females) were found to have Barrett's esophagus.

    Seven of 177 were found to have adenocarcinoma either at initial endoscopy or within 6 months, resulting in a prevalence of 4%. One hundred seventy of 177 patients initially lacking cancer were available for systematic survey.

    Results 

    The mean age at the time of Barrett's diagnosis was 62 yr (range 30-85 yr).

    The mean follow-up period was 57 months or 4.8 yr (range 6-156 months), for a total of 834 patient-years.

    Adenocarcinoma developed in four patients, an incidence of 1/208 patient-years of follow-up.

    Conclusions 

    The current series is larger and has a longer follow-up period than previous prospective trials and demonstrates a lower incidence of adenocarcinoma.

    Surveillance of patients with Barrett's esophagus for dysplasia remains an appropriate clinical practice.

    Mots-clés Pascal : Oesophage Barrett, Facteur risque, Complication, Carcinome, Oesophage, Incidence, Association morbide, Epidémiologie, Homme, Appareil digestif pathologie, Oesophage pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Barrett esophagus, Risk factor, Complication, Carcinoma, Esophagus, Incidence, Concomitant disease, Epidemiology, Human, Digestive diseases, Esophageal disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0187102

    Code Inist : 002B13A01. Création : 21/05/1997.