Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949.
Temperance boards were established in Sweden to register and follow up individuals who were seen in legal or medical settings with problems of alcohol abuse.
These records, available in a large epidemiologic twin population, have provided an objective and validated measure of alcohol abuse.
We examined Swedish temperance board registrations from 1929 to 1974 (n=2516 individual twins) in all male-male Swedish twin pairs of known zygosity from the population-based Swedish Twin Registry ; these twin pairs were born from 1902 to 1949 (n=8935 pairs).
The lifetime prevalence and probandwise concordance rates for temperance board registrations were 13.2% and 47.9%, respectively, in monozygotic twins and 14.6% and 32.8%, respectively, in dizygotic twins.
Model fitting suggested that genetic and familial-environmental risk factors accounted for 54% (95% confidence interval [CI], 47% - 61%) and 14% (95% CI, 8% - 19%) of the liability to temperance board registration, respectively ; these estimates were stable across birth cohorts.
High genetic liability was reflected by large numbers of temperance board registrations and registrations for criminal alcohol use.
Elevated familial-environmental liability was indicated by an early age at first registration.
Genetic factors are of major etiologic importance for alcohol abuse in men, while familial-environmental factors play a significant but less important role. (...)
Mots-clés Pascal : Alcoolisme, Dossier médical, Etiologie, Déterminisme génétique, Interaction génotype environnement, Jumeau monozygote, Jumeau dizygote, Mâle, Etude familiale, Homme, Epidémiologie
Mots-clés Pascal anglais : Alcoholism, Medical record, Etiology, Genetic inheritance, Genotype environment interaction, Monozygotic twin, Dizygotic twin, Male, Family study, Human, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0187053
Code Inist : 002B18C05B. Création : 21/05/1997.