Temperance boards were established in Sweden to register and follow up individuals who were seen in legal or medical settings with problems of alcohol abuse.
These records, available in a large epidemiologic twin population, have provided an objective and validated measure of alcohol abuse.
We examined Swedish temperance board registrations from 1929 to 1974 (n=2516 individual twins) in all male-male Swedish twin pairs of known zygosity from the population-based Swedish Twin Registry ; these twin pairs were born from 1902 to 1949 (n=8935 pairs).
The lifetime prevalence and probandwise concordance rates for temperance board registrations were 13.2% and 47.9%, respectively, in monozygotic twins and 14.6% and 32.8%, respectively, in dizygotic twins.
Model fitting suggested that genetic and familial-environmental risk factors accounted for 54% (95% confidence interval [CI], 47% - 61%) and 14% (95% CI, 8% - 19%) of the liability to temperance board registration, respectively ; these estimates were stable across birth cohorts.
High genetic liability was reflected by large numbers of temperance board registrations and registrations for criminal alcohol use.
Elevated familial-environmental liability was indicated by an early age at first registration.
Genetic factors are of major etiologic importance for alcohol abuse in men, while familial-environmental factors play a significant but less important role. (...)
Mots-clés Pascal : Alcoolisme, Dossier médical, Etiologie, Déterminisme génétique, Interaction génotype environnement, Jumeau monozygote, Jumeau dizygote, Mâle, Etude familiale, Homme, Epidémiologie
Mots-clés Pascal anglais : Alcoholism, Medical record, Etiology, Genetic inheritance, Genotype environment interaction, Monozygotic twin, Dizygotic twin, Male, Family study, Human, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0187053
Code Inist : 002B18C05B. Création : 21/05/1997.