In recent years, several regulatory agencies and professional societies have recommended an occupational exposure limit (OEL) for formaldehyde.
This article presents the findings of a panel of experts, the Industrial Health Foundation panel, who were charged to identify an OEL that would prevent irritation.
To accomplish this task, they critiqued approximately 150 scientific articles.
Unlike many other chemicals, a large amount of data is available upon which to base a concentration-response relationship for human irritation.
A mathematical model developed by Kane et al. (1979) for predicting safe levels of exposure to irritants based on animal data was also evaluated.
The panel concluded that for most persons, eye irritation clearly due to formaldehyde does not occur until at least 1.0 ppm.
Information from controlled studies involving volunteers indicated that moderate to severe eye, nose, and throat irritation does not occur for most persons until airborne concentrations exceed 2.0-3.0 ppm.
The data indicated that below 1.0 ppm, if irritation occurs in some persons, the effects rapidly subside due to « accommodation. » Based on the weight of evidence from published studies, the panel found that persons exposed to 0.3 ppm for 4-6 h in chamber studies generally reported eye irritation at a rate no different than that observed when persons were exposed to clean air.
It was noted that at a concentration of 0. (...)
Mots-clés Pascal : Recommandation, Dose limite, Exposition professionnelle, Médecine travail, Homme, Toxicité, Aigu, Subchronique, Chronique, Formaldéhyde, Aldéhyde, Animal, Relation dose réponse, Oeil pathologie, Article synthèse
Mots-clés Pascal anglais : Recommendation, Limit dose, Occupational exposure, Occupational medicine, Human, Toxicity, Acute, Subchronic, Chronic, Formaldehyde, Aldehyde, Animal, Dose activity relation, Eye disease, Review
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0186395
Code Inist : 002B03L06. Création : 21/05/1997.