Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population : the Hoorn Study.
Cross-sectional associations between carotid artery stenosis (CAS) on the one hand, and parameters of glycaemia and specific insulin levels on the other, were investigated in an age, sex, and glucose tolerance stratified random sample from a 50-74-year-old Caucasian population.
Subjects treated with insulin or oral hypoglycaemic agents were classified as having known diabetes mellitus (KDM) (n=66).
Using two oral glucose tolerance tests, and based on the World Health Organisation criteria, all other participants were classified as having a normal (NGT) (n=287), an impaired (IGT) (n=169) or a diabetic (NDM) (n=106) glucose tolerance.
CAS was defined haemodynamically using duplex scanning.
The crude prevalences of only moderate (16-49%) CAS were 6.6%, 7.1%, 5.7% and 12.1% in NGT, IGT, NDM and KDM subjects, respectively.
For any severe (=50%) CAS, crude prevalences were 2.8%, 4.7%, 9.4% and 7.6%. The prevalence of any severe CAS was higher in NDM (p<0.01) and KDM subjects (p=0.07) than in NGT subjects.
The prevalence of a history of stroke or transient ischaemic attack was 1.7%, 1.8%, 2.8% and 1.5% in NGT, IGT, NDM and KDM, respectively.
In univariate logistic regression analysis, HbA1c, serum fructosamine, fasting and 2-h post-load glucose were significantly associated with any severe CAS.
In multivariate analyses controlling for other risk factors, only HbA1c and 2-h post-load plasma glucose remained significantly associated (odds ratios : 1.29 per% and 1. (...)
Mots-clés Pascal : Caucasoïde, Epidémiologie, Diabète non insulinodépendant, Hyperglycémie provoquée, Facteur risque, Sténose, Carotide, Système nerveux pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie, Système nerveux central pathologie, Homme, Insuline
Mots-clés Pascal anglais : Caucasoid, Epidemiology, Non insulin dependent diabetes, Glucose tolerance test, Risk factor, Stenosis, Carotid, Nervous system diseases, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease, Arterial disease, Central nervous system disease, Human, Insulin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0186358
Code Inist : 002B12B03. Création : 21/05/1997.