This paper draws together the mortality experience for a cohort of some 11 000 male Quebec Chrysotile miners and millers, reported at intervals since 1971 and now again updated.
Of the 10918 men in the complete cohort, 1138 were lost to view, almost all never traced after employment of only a month or two before 1935 ; the other 9780 men were traced into 1992.
Of these, 8009 (82%) are known to have died : 657 from lung cancer, 38 from mesotheliona, 1205 from other malignant disease, 108 from pneumoconiosis and 561 from other non-malignant respiratory diseases (excluding tuberculosis).
After early fluctuations, SMRs (all causes) against Quebec rates have been reasonably steady since about 1945.
For men first employed in Asbestos, mine or factory, they were very much what might have been expected for a blue collar population without any hazardous exposure.
SMRs in the Thetford Mines area were almost 8% higher, but in line with anecdotal evidence concerning socio-economic status.
At exposures below 300 (million particles per cubic foot) x years, (mpcf. y), equivalent to roughly 1000 (fibres/ml) x years-or, say, 10 years in the 1940s at 80 (fibres/ml) - findings were as follows.
There were no discernible associations of degree of exposure and SMRs, whether for all causes of death or for all the specific cancer sites examined.
The average SMRs were 1.07 (all causes), and 1.16,0.93,1.03 and 1.21, respectively, for gastric, other abdominal, laryngeal and lung cancer. (...)
Mots-clés Pascal : Amiante, Fibre minérale, Toxicité, Exposition professionnelle, Médecine travail, Historique, Québec, Canada, Amérique du Nord, Amérique, Etude cohorte, Mortalité, Homme, Chrysotile, Tumeur maligne, Tabagisme, Epidémiologie, Mésothéliome, Bronchopulmonaire, Etude longitudinale
Mots-clés Pascal anglais : Asbestos, Mineral fiber, Toxicity, Occupational exposure, Occupational medicine, Case history, Quebec, Canada, North America, America, Cohort study, Mortality, Human, Malignant tumor, Tobacco smoking, Epidemiology, Mesothelioma, Bronchopulmonary, Follow up study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0186050
Code Inist : 002B03L03. Création : 21/05/1997.