Cow hair allergen (Bos d 2) content in house dust : Correlation with sensitization in farmers with cow hair asthma.
Farmers (N=45) suffering from occupational cow hair asthma were visited at home to evaluate the concentration of cow hair major allergen Bos d 2 in the house dust and to correlate these results with measures of avoidance, degree of sensitization, clinical symptoms, and lung function.
Bos d 2 was determined by rocket immunoelectrophoresis.
In dust oftiles and linoleum Bos d 2 was difficult to detect, whereas dust samples of carpets often contained high concentrations of the allergen (50-520 mug/g fine dust).
Bos d 2 levels were significantly higher when barn and living quarters were in the same building.
Concentrations of cow hair-specific IgE were correlated with concentrations of Bos d 2 in house dust samples.
A concentration of 20-29 mug Bos d 2 per gram of house dust could be established as threshold value for relevant IgE sensitization.
Avoiding the barn is not a sufficient avoidance measure for cow hair asthmatics if the partner continues cattle farming.
Cessation of cattle farming and avoiding the former barn results in a marked reduction in Bos d 2 concentration in living quarters, a decreased degree of sensitization, and a reduced symptom score.
Farmers with cow hair asthma should avoid cattle and thoroughly clean all carpets in the living quarters to avoid continuous cow allergen exposure.
Mots-clés Pascal : Asthme, Etiologie, Allergène, Allergie, Poil, Vache, Boeuf, Artiodactyla, Ungulata, Mammalia, Vertebrata, Poussière maison, Concentration, Sensibilisation, Exposition professionnelle, Agriculteur, Allemagne, Europe, Prévention, Evitement, Homme, Animal, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Maladie professionnelle, Médecine travail, Pneumallergène
Mots-clés Pascal anglais : Asthma, Etiology, Allergen, Allergy, Hair, Cow, Ox, Artiodactyla, Ungulata, Mammalia, Vertebrata, House dust, Concentration, Sensitization, Occupational exposure, Farmer, Germany, Europe, Prevention, Avoidance, Human, Animal, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational disease, Occupational medicine, Aeroallergen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0183467
Code Inist : 002B06C02. Création : 21/05/1997.