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  1. Attributable risks for breast cancer in Italy : Education, family history and reproductive and hormonal factors.

    Article - En anglais

    The percent population attributable risk (AR) for breast cancer was estimated in relation to education, family history of the disease and some reproductive and hormonal factors, using data from a case-control study conducted between June 1991 and February 1994 in 6 Italian centres on 2,569 histologically confirmed incident breast cancer cases and 2,588 controls, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases.

    On the basis of multivariate odds ratios, a high level of education accounted for 20% of cases, elevated age at first birth and nulliparity for 38% and a family history of breast cancer in first-degree relatives for 7%. Education and nulliparity and age at first birth together explained 47% of all breast cancer cases, and the combination of these 2 factors plus a family history of the disease explained 50% of cases.

    In pre-menopausal women a high level of education accounted for 31% of all breast cancer cases, older age at first birth for 44% and the combination of the 2 factors for 49%. In post-menopausal women the corresponding values were 13%, 31% and 42% ; further addition of risk associated with family history of the disease explained 52% of pre-menopausal cases.

    In post-menopausal women older age at menopause and the use of hormone replacement therapy accounted for 15% and 2% of breast cancer cases, respectively. (...)

    Mots-clés Pascal : Tumeur maligne, Glande mammaire, Epidémiologie, Homme, Femelle, Gestation, Age, Parité, Ménopause, Niveau étude, Histoire familiale, Italie, Europe, Etude multicentrique, Etude cas témoin, Facteur risque, Glande mammaire pathologie

    Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Epidemiology, Human, Female, Pregnancy, Age, Parity, Menopause, Education level, Family story, Italy, Europe, Multicenter study, Case control study, Risk factor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0181259

    Code Inist : 002B20E02. Création : 21/05/1997.