The percent population attributable risk (AR) for breast cancer was estimated in relation to education, family history of the disease and some reproductive and hormonal factors, using data from a case-control study conducted between June 1991 and February 1994 in 6 Italian centres on 2,569 histologically confirmed incident breast cancer cases and 2,588 controls, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases.
On the basis of multivariate odds ratios, a high level of education accounted for 20% of cases, elevated age at first birth and nulliparity for 38% and a family history of breast cancer in first-degree relatives for 7%. Education and nulliparity and age at first birth together explained 47% of all breast cancer cases, and the combination of these 2 factors plus a family history of the disease explained 50% of cases.
In pre-menopausal women a high level of education accounted for 31% of all breast cancer cases, older age at first birth for 44% and the combination of the 2 factors for 49%. In post-menopausal women the corresponding values were 13%, 31% and 42% ; further addition of risk associated with family history of the disease explained 52% of pre-menopausal cases.
In post-menopausal women older age at menopause and the use of hormone replacement therapy accounted for 15% and 2% of breast cancer cases, respectively. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Epidémiologie, Homme, Femelle, Gestation, Age, Parité, Ménopause, Niveau étude, Histoire familiale, Italie, Europe, Etude multicentrique, Etude cas témoin, Facteur risque, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Epidemiology, Human, Female, Pregnancy, Age, Parity, Menopause, Education level, Family story, Italy, Europe, Multicenter study, Case control study, Risk factor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0181259
Code Inist : 002B20E02. Création : 21/05/1997.