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  1. Methadone maintenance and other factors associated with intraindividual temporal trends in injection-drug use.

    Article - En anglais

    The objective of this study was to determine what sociodemographic, lifestyle, or drug-related characteristics predict temporal changes in self-reported drug injection frequencies among HIV-seronegative injection-drug users (IDUs) who were being given HIV testing and risk reduction counseling.

    The 277 subjects were given 4-11 quarterly interviews including a detailed history ofdrug use and other HIV risk factors, HIV risk reduction counseling, and venipuncture for HIV antibody testing.

    A regression slope of change over time in drug injection frequency was calculated for each subject, and categories were created of decreasing temporal slope, increasing slope, relapse (decrease initially, then increase), or no substantial change.

    Only 44% of subjects decreased their drug injection frequencies despite repetitive HIV testing and counseling.

    In multivariate logistic analyses, decreasing temporal trends were associated with consistent enrollment in methadone maintenance (p<. 1), whereas increasing trends conversely were associated with inconsistent enrollment (p<. 01) and also with an absence of crack use (p<. 01).

    Relapses were significantly associated with needle sharing with multiple partners and a low frequency ofsmoking.

    The data suggest that methadone maintenance facilitates a positive response to HIV risk reduction counseling. (...)

    Mots-clés Pascal : Toxicomanie, Sevrage toxique, Chimiothérapie, Méthadone, Analgésique narcotique, Traitement substitutif, Comportement, Santé, Prise risque, Voie intraveineuse, Changement comportement, Homme, Opiacés

    Mots-clés Pascal anglais : Drug addiction, Poison withdrawal, Chemotherapy, Methadone, Narcotic analgesic, Replacement therapy, Behavior, Health, Risk taking, Intravenous administration, Behavior change, Human, Opiates

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0181146

    Code Inist : 002B18C05A. Création : 21/05/1997.