The effects of smoking on the 8-year (1984-1992) incidence of non-insulin-dependent diabetes mellitus (NIDDM) were investigated in a cohort of 2,312 male employees of an electrical company in Japan.
The incidence rate was 2.2/1,000 person-years.
After controlling for other known risk factors for NIDDM, a proportional hazards regression analysis indicated that those who were currently smoking 16-25 cigarettes per day had a 3.27 times higher risk of developing NIDDM during the follow-up period than never smokers (p<0.05) ; the hazard ratio was similar (3.21) for those who were currently smoking = 26 cigarettes per day.
Among ever smokers, proportional hazards regression analysis also indicated that younger age at starting smoking was associated with an increased risk of NIDDM (p for trend=0.09).
These findings suggest that number of cigarettes smoked per day is important in the relation between smoking and NIDDM incidence, although the risks did not increase above a given amount of smoking.
Starting smoking at a younger age also might be independently associated with an increased risk of NIDDM.
Mots-clés Pascal : Diabète non insulinodépendant, Epidémiologie, Homme, Tabagisme, Etude longitudinale, Japon, Asie, Toxicité, Age apparition, Cigarette, Sevrage toxique, Incidence, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Epidemiology, Human, Tobacco smoking, Follow up study, Japan, Asia, Toxicity, Age of onset, Cigarette, Poison withdrawal, Incidence, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0180914
Code Inist : 002B03E. Création : 21/05/1997.