An increased albumin excretion rate (AER) is associated with impaired glucose tolerance and diabetes mellitus in some populations, but data on Americans of Northern European origin are lacking.
In 1986-1987, AER and creatinine clearance were measured in 455 adults in a survey of the population of Wadena, Minnesota.
Thirty-five subjects (8%) had an AER = 15 mug/minute, and eight of these had overt proteinuria (AER = 175 mug/minute).
AER and creatinine clearance were uncorrelated except when AER was increased.
Unadjusted mean AER in a stratified random sample of adults (n=374) was 3.6 mug/minute.
Adjusted values for 277 subjects with normal glucose tolerance and for 80 subjects with impaired glucose tolerance were very similar (3.8 and 3.7 mug/minute, respectively), whereas mean AER was 5.4 mug/minute for persons with non-insulin-dependent diabetes mellitus (NIDDM) who were not taking insulin and 9.4 mug/minute for persons with NIDDM who were taking insulin (p<0.0001).
After adjustment for age, mean creatinine clearance was unrelated to glucose tolerance.
Systolic blood pressure was a major determinant of increased AER (p<0.0001) and lowered creatinine clearance (p=0.0011), independently of diabetes.
AER was stable over 5 years among the 321 cases who were not taking insulin and were not severely hypertensive.
The decrease in creatinine clearance was greater in ex-smokers and current smokers than in nonsmokers. (...)
Mots-clés Pascal : Rein pathologie, Epidémiologie, Facteur risque, Adulte, Homme, Minnesota, Etats Unis, Amérique du Nord, Amérique, Anomalie tolérance glucose, Albumine, Pression sanguine, Hémodynamique, Créatinine, Prospective, Appareil urinaire pathologie, Endocrinopathie
Mots-clés Pascal anglais : Kidney disease, Epidemiology, Risk factor, Adult, Human, Minnesota, United States, North America, America, Impaired glucose tolerance, Albumin, Blood pressure, Hemodynamics, Creatinine, Prospective, Urinary system disease, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0180913
Code Inist : 002B14E01. Création : 21/05/1997.