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  1. Fulltext. Risk factors for kidney damage in the adult population of Wadena, Minnesota : A prospective study.

    Article - En anglais


    An increased albumin excretion rate (AER) is associated with impaired glucose tolerance and diabetes mellitus in some populations, but data on Americans of Northern European origin are lacking.

    In 1986-1987, AER and creatinine clearance were measured in 455 adults in a survey of the population of Wadena, Minnesota.

    Thirty-five subjects (8%) had an AER = 15 mug/minute, and eight of these had overt proteinuria (AER = 175 mug/minute).

    AER and creatinine clearance were uncorrelated except when AER was increased.

    Unadjusted mean AER in a stratified random sample of adults (n=374) was 3.6 mug/minute.

    Adjusted values for 277 subjects with normal glucose tolerance and for 80 subjects with impaired glucose tolerance were very similar (3.8 and 3.7 mug/minute, respectively), whereas mean AER was 5.4 mug/minute for persons with non-insulin-dependent diabetes mellitus (NIDDM) who were not taking insulin and 9.4 mug/minute for persons with NIDDM who were taking insulin (p<0.0001).

    After adjustment for age, mean creatinine clearance was unrelated to glucose tolerance.

    Systolic blood pressure was a major determinant of increased AER (p<0.0001) and lowered creatinine clearance (p=0.0011), independently of diabetes.

    AER was stable over 5 years among the 321 cases who were not taking insulin and were not severely hypertensive.

    The decrease in creatinine clearance was greater in ex-smokers and current smokers than in nonsmokers. (...)

    Mots-clés Pascal : Rein pathologie, Epidémiologie, Facteur risque, Adulte, Homme, Minnesota, Etats Unis, Amérique du Nord, Amérique, Anomalie tolérance glucose, Albumine, Pression sanguine, Hémodynamique, Créatinine, Prospective, Appareil urinaire pathologie, Endocrinopathie

    Mots-clés Pascal anglais : Kidney disease, Epidemiology, Risk factor, Adult, Human, Minnesota, United States, North America, America, Impaired glucose tolerance, Albumin, Blood pressure, Hemodynamics, Creatinine, Prospective, Urinary system disease, Endocrinopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0180913

    Code Inist : 002B14E01. Création : 21/05/1997.