Toxicology and epidemiology of 1,3-butadiene.
1,3-Butadiene is a colorless, volatile gas that has high-volume usage in the synthesis of polybutadiene, styrene-butadiene, and other polymers.
Due to its volatile nature, uptake of butadiene occurs almost exclusively by inhalation and absorption through the respiratory system.
Sources of exposure include production, transport, and end-use processes in industrial settings or environmental exposures through automotive fuel, fossil fuel combustion, and cigarette smoke.
Chronic inhalation studies established that butadiene is carcinogenic in B6C3F1 mice and Sprague-Dawley rats, and that mice are considerably more sensitive than rats.
For the most part, epidemiologic studies for butadiene have been equivocal, although a recent retrospective follow-up study of styrene-butadiene rubber workers provides the first internally consistent evidence of a relationship between butadiene exposure and leukemia.
The mechanism (s) of butadiene-induced carcinogenicity are not entirely understood but are thought to involve covalent interactions of the butadiene epoxide metabolites, epoxybutene and diepoxybutane, with DNA.
Species differences in butadiene metabolism are evident.
In vitro and in vivo studies clearly reveal that mice have a higher capacity to form reactive epoxides than rats or humans.
This is reflected by the very high levels of epoxides in blood and tissues of mice compared with rats exposed to butadiene. (...)
Mots-clés Pascal : Butadiène, In vivo, Gaz, Composé volatil, Toxicité, Article synthèse, Monographie, Animal, Homme, Carcinogène, Mécanisme action, Epidémiologie, Métabolisme, Toxicocinétique, Surveillance biologique, Marqueur biologique, In vitro, Mutagène, Exposition professionnelle, Médecine travail, Buta-1,3-diène
Mots-clés Pascal anglais : Butadiene, In vivo, Gases, Volatile compound, Toxicity, Review, Monograph, Animal, Human, Carcinogen, Mechanism of action, Epidemiology, Metabolism, Toxicokinetics, Biological monitoring, Biological marker, In vitro, Mutagen, Occupational exposure, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0178025
Code Inist : 002B03L02. Création : 21/05/1997.