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  1. Serologic survey for control of hepatitis C in haemodialysis patients : third-generation assays and analysis of costs.

    Article - En anglais

    There is little information about the serologic survey for control of hepatitis C by using third-generation assays among chronic haemodialysis (HD) patients, and no analysis of costs has been made to this end.

    A serologic survey for control of hepatitis C was performed in 190 HD patients attending a single dialysis unit, using second-and third-generation assays.

    Costs of both serologic surveys were calculated.

    Anti-HCV prevalence tested by third-generation assays increased from 25% (48/190) to 28% (53/190) compared to second-generation testing ; 56% (9/16) of patients showing uncertain findings by second-generation tests gave unequivocal results by third-generation assays ; median duration of HD treatment and raised aminotransferase levels were positively associated (P=0.004 and P=0.012, respectively) with anti-HCV detected by third-generation assays.

    The serologic survey for control of hepatitis C in HD patients at our centre was slightly more expensive by third-generation assays compared to second-generation testing (US$ 18 866 vs US$17 200 per year).

    In summary, the use of third-generation tests largely clarified the uncertain results of second-generation tests ; new additional positive patients were detected by third-generation assays compared to second-generation testing.

    Third-generation assays showed the association of duration of HD treatment and raised aminotransferase levels with anti-HCV antibody, as previously found by first-and second-generation assays. (...)

    Mots-clés Pascal : Hémodialyse, Complication, Hépatite virale C, Virose, Infection, Diagnostic, Exploration virologique, Sérologie, Examen laboratoire, Technique, Coût, Etude comparative, Homme, Epuration extrarénale, Appareil digestif pathologie, Foie pathologie, Economie santé

    Mots-clés Pascal anglais : Hemodialysis, Complication, Viral hepatitis C, Viral disease, Infection, Diagnosis, Virological exploration, Serology, Laboratory investigations, Technique, Costs, Comparative study, Human, Extrarenal dialysis, Digestive diseases, Hepatic disease, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0177748

    Code Inist : 002B24O06. Création : 21/05/1997.