Prospective evaluation of prostate specific antigen and prostate specific antigen density in the detection of carcinoma of the prostate : Ethnic variations. Commentary.
We evaluated prospectively the ethnic variations in prostate specific antigen (PSA) and prostate specific antigen density in the detection of carcinoma of the prostate.
Materials and Methods
A total of 297 consecutive patients with an elevated serum PSA and/or abnormal digital rectal examination underwent transrectal ultrasound with lesion directed and systematic biopsy (6 if the prostatic volume was 50 cc or less and 12 if it was greater than 50 cc).
Receiver operating characteristic curves, predictive values and likelihood ratios were calculated for PSA and PSA density for white and black patients.
Ethnic analysis was performed for the entire group, patients with a normal digital rectal examination, and those with a normal digital rectal examination and PSA of 4 to 10 ng./ml.
Of the 297 patients 131 (44%) had cancer, including 48 of 97 black (50%) and 83 of 200 white (42%) patients.
Median PSA, PSA density and prostate size did not differ between the positive or negative biopsy groups, or between the ethnic groups in any of the analyses.
If all digital rectal examinations were considered PSA density was superior to PSA by receiver operating characteristic analysis for cancer detection in both ethnic groups when all values or PSA of 4 to 10 ng./ml. were considered.
However, the significance was lost if only patients with a normal digital rectal examination were considered.
In general, predictive values were greater in black patients. (...)
Mots-clés Pascal : Adénocarcinome, Prostate, Diagnostic, Dosage, Densité, Antigène spécifique prostate, Taille, Effet biologique, Origine ethnique, Etude statistique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie
Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Diagnosis, Assay, Density, Prostate specific antigen, Size, Biological effect, Ethnic origin, Statistical study, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0177665
Code Inist : 002B14D02. Création : 21/05/1997.