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  1. Tuberculosis then and now : A personal perspective on the last 50 years.

    Article - En anglais

    Rates of death from tuberculosis in the United States decreased from 194 per 100 000 persons in 1900 to 40 per 100 000 persons in 1945, in part because the epidemic of tuberculosis in the western world was running its course and in part because of public health initiatives and improved socioeconomic conditions.

    In 1945,63 000 persons died of tuberculosis and 115 000 new cases of the disease emerged.

    Streptomycin and para-aminosalicylic acid had just been discovered ; the discovery of isoniazid followed, in 1952.

    Sanitarium care, nonsurgical and surgical collapse therapy, and resectional surgery were in widespread use.

    By the middle of the 1950s, it was evident that bedrest did not add to the benefit produced by effective chemotherapy, and sanitariums began to close, a process that was completed by the 1970s.

    As mortality and morbidity due to tuberculosis rapidly decreased, the U.S. government decreased funding for tuberculosis and many states and cities downgraded their tuberculosis control programs.

    After 1984, the rate of new cases of tuberculosis, which had decreased to 9.4 per 100 000, began to increase and focal outbreaks of multidrug-resistant tuberculosis were reported.

    Noncompliance with drug therapy, homelessness, immigration to the United States from developing countries, and human immunodeficiency virus (HIV) infection were invoked as explanations. (...)

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Endémie, Prévalence, Evolution, Homme, Epidémiologie

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Endemy, Prevalence, Evolution, Human, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0176968

    Code Inist : 002B05B02O. Création : 21/05/1997.