The observed prevalence of hemochromatosis has ranged considerably from 0.05 to 0.37% in studies requiring liver biopsy.
We aimed to study the prevalence of genetic hemochromatosis among Norwegian blood donors.
We studied 10552 healthy blood donors (5312 women and 5240 men) using serum ferritin as a screening parameter.
If serum ferritin concentration was =100 mug/l in women and =200 mug/l in men, serum iron and transferrin (measured as total iron binding capacity=TIBC) were measured.
Blood donors who repeatedly had a transferrin saturation above 40% and a ferritin concentration above these limits were referred to a hepatologist (H.B.). Results : Serum ferritin was =100 mug/l in 94/5312 (1.8%) women and =200 mul in 79/5240 (1.5%) men.
Of these, 37 persons had a serum ferritin concentration above 100 mug/l (females) or above 200 mug/l (males) and a transferrin saturation above 40%. Nineteen of them (13 men and 6 women, median age 36 years, range 28-68) were identified as having hemochromatosis on the basis of increased hepatic iron index.
Serum ferritin ranged from 111 to 1980 mug/l (median 357 mug/l and transferrin saturation from 50 to 100% (median 92%), hepatic iron from 48 to 471 mumol/g dry weight (median 118 mumol/g) and hepatic iron index from 1.5 to 12.1 (median 3.0).
One person had cirrhosis and none had diabetes.
The prevalence of hemochromatosis was significantly higher among first-time blood donors (12 out of 3500 [3. (...)
Mots-clés Pascal : Hémochromatose, Asymptomatique, Incidence, Dépistage, Donneur sang, Etude statistique, Homme, Norvège, Europe, Pigment, Métabolisme pathologie, Enzymopathie
Mots-clés Pascal anglais : Hemochromatosis, Asymptomatic, Incidence, Medical screening, Blood donor, Statistical study, Human, Norway, Europe, Pigments, Metabolic diseases, Enzymopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0176576
Code Inist : 002B22E03. Création : 21/05/1997.