To investigate the immunogenicity of two versus three injections of inactivated strain CR326F-derived hepatitis A vaccine in healthy adults.
Healthy adult volunteers (n=105) at Utrecht University Hospital, The Netherlands, were randomly assigned to receive intramuscular injections (deltoid muscle) of 25 Units (U) at 0 and 6 months (group A, n=53), or at 0,2 and 6 months (group B, n=52).
Blood was drawn before and at various time points after vaccination for determination of serum antibody to hepatitis A (anti-HAV).
One month after the first injection, the seroconversion rates (=10 mIU/ml, international units) were 88% for group A and 90% for group B. Only 2/103 (one in each group) showed IgM anti-HAV.
One month after the second injection, seroconversion rates were 100% in both groups.
At months 3,6 and 7, anti-HAV geometric mean titers were significantly different because of the different vaccination schedules, but they were similar at months 1,2 and 12.
The anti-HAV geometric mean titer increase after the second injection was higher when the interval between the two doses was of longer duration.
Anti-HAV titers of females were significantly higher than those of males and vaccinees ¾30 years had higher titers than those>30 years.
Two 25 U doses of the vaccine investigated given at 0 and 6 months, induce adequate anti-HAV titers in all adult healthy vaccinees and are as immunogenic as three doses given at 0,2 and 6 months.
Mots-clés Pascal : Hépatite virale A, Virose, Infection, Prévention, Vaccination, Dose efficace, Injection, Immunogénicité, Inactivité biologique, Vaccin, Evaluation performance, Etude comparative, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Prevention, Vaccination, Effective dose, Injection, Immunogenicity, Biological inactivity, Vaccine, Performance evaluation, Comparative study, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0176569
Code Inist : 002B05A02. Création : 21/05/1997.