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  1. Decrease in HDV endemicity in Italy.

    Article - En anglais

    Background/Aims 

    To evaluate a possible variation in hepatitis D virus endemicity in Italy, the data from a multicentre study concerning HBsAg chronic carriers first observed in 31 liver units during 1992 were compared with the corresponding figures from a similar study performed in 1987.

    Methods/Results 

    In both studies the methodology for the recruitment of cases was the same.

    The overall anti-HD prevalence in 1992 was 14.4%, a significantly lower rate than that observed in 1987 (23.4%, p<0.01).

    The decrease significantly (p<0.01) affected both males and females ; it occurred in all geographical areas, although to a greater extent in northern regions.

    It was evident in subjects below 50 years of age, but not in subjects older than 50.

    A significant reduction in the anti-HD prevalence was seen in all forms of chronic hepatitis.

    Conclusions 

    These findings indicate a lower level of hepatitis D virus endemicity in Italy, probably as a consequence of the reported decreased pool of HBsAg chronic carriers, the reduced size of families, the improved socio-economic conditions and changes in intravenous drug abuser behaviour.

    All these factors may have affected the strength of hepatitis D virus infection which has greatly reduced the spread of the virus.

    Mots-clés Pascal : Hépatite virale delta, Virose, Infection, Chronique, Dosage, Antigène, Evolution, Incidence, Epidémiologie, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis delta, Viral disease, Infection, Chronic, Assay, Antigen, Evolution, Incidence, Epidemiology, Human, Italy, Europe, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0176270

    Code Inist : 002B05C02G. Création : 21/05/1997.