Suppression of the immune response to diphtheria toxoid in murine schistosomiasis.
Studies in humans and experimental animals indicate that infection with schistosomes results in impaired immune response to a variety of antigens.
Since artificial immunization against a number of infections is frequently attempted in populations in which schistosomiasis is endemic, we have attempted to determine whether this impairment could be demonstrated in response to a commonly used immunogen.
We have compared the serum antitoxin response to diphtheria toxoid (DTd) in normal, uninfected mice with that in mice bearing schistosome infections of different duration.
Animals were infected with 100 Schistosoma mansoni cercariae 16,12,8,4 and 2 weeks prior to, on the same day as, and 4 weeks after the first of three 1 mug doses of DTd given at 3 week intervals.
The antitoxin level of each mouse was taken as the mean of two sera obtained 1 and 2 weeks after the 3rd dose of DTd.
The mean antitoxin level in uninfected-immunized control mice was 0.0457 Antitoxin Units (A U) ml-1. 71% of mice in this group developed antitoxin levels =0.01 AU ml-1.
Only 28% of the infected-immunized mice achieved antitoxin levels =0.01 AU ml-1.
In infected-immunized mice with infections of all durations, both the percentage of mice with = 0.01 AU ml-1 (0 to 50%) and mean antitoxin levels (0.003 to 0.016 AU ml-1) were lower than in uninfected-immunized mice. (...)
Mots-clés Pascal : Schistosomiase, Trématodose, Helminthiase, Parasitose, Infection, Schistosoma mansoni, Trematoda, Plathelmintha, Helmintha, Invertebrata, Anatoxine, Corynebacterium diphtheriae, Corynebacteriaceae, Actinomycetes, Bactérie, Immunomodulation, Immunodépression, Réponse immune, Immunité humorale, Anticorps, Souris, Rodentia, Mammalia, Vertebrata
Mots-clés Pascal anglais : Schistosomiasis, Trematode disease, Helminthiasis, Parasitosis, Infection, Schistosoma mansoni, Trematoda, Plathelmintha, Helmintha, Invertebrata, Toxoid, Corynebacterium diphtheriae, Corynebacteriaceae, Actinomycetes, Bacteria, Immunomodulation, Immunosuppression, Immune response, Humoral immunity, Antibody, Mouse, Rodentia, Mammalia, Vertebrata
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0175822
Code Inist : 002B05E03C1. Création : 21/05/1997.