Objectives-To examine the incidence and mortality of cancer near the Pan Britannica Industries factory, Waltham Abbey, after reports of a possible cluster of all cancers and brain cancer in the vicinity.
Method-Small area study of cancer incidence 1977-89, and mortality 1981-92, within a 7.5 km radius of the factory site.
Postcoded cancer registrations and deaths in the study area were extracted from national data sets held by the Small Area Health Statistics Unit and compared with expected numbers computed by applying national rates stratified for age, sex, and deprivation to the local population (1981 and 1991 censuses).
Observed expected (O/E) ratios were examined from 0-1 km and 0-7.5 km of the plant, and tests applied for a decline in relative risk with distance up to 7.5 km.
There were 12 859 incident cancers (1977-89) from 0-7.5 km (O/E ratio 1.04 ; 95% confidence interval (95% CI) 1.02 to 1.06) and 385 from 0-1 km (O/E 1.10 ; 1.00 to 1.22).
There was an excess of skin melanoma from 0-1 km based on 11 cases (O/E 2.13 ; 1.06 to 3.80), and an excess from 0-7.5 km of cancer of the lung, stomach and pancreas combined, and prostate (O/Es ranged from 1.09 to 1.13).
Only the findings from lung cancer were suggestive of a decline in risk with distance, especially in the later period (1982-9).
There were 9196 cancer deaths (1981-92) from 0-7.5 km (O/E 1.04 ; 95% CI 1.02 to 1.06) and 308 from 0-1 km (O/E 1.24 ; 1.11 to 1.39) ; and 25 507 non-cancer deaths (O/E 1. (...)
Mots-clés Pascal : Tumeur maligne, Exposition professionnelle, Carcinogène, Pesticide, Industrie chimique, Homme, Epidémiologie, Toxicité, Incidence, Mortalité, Non professionnel, Pollution, Zone résidentielle, Environnement, Royaume Uni, Europe
Mots-clés Pascal anglais : Malignant tumor, Occupational exposure, Carcinogen, Pesticides, Chemical industry, Human, Epidemiology, Toxicity, Incidence, Mortality, Non occupational, Pollution, Residential zone, Environment, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0175432
Code Inist : 002B04B. Création : 21/05/1997.