To study the nephrotoxic effects of occupational exposure to antineoplastic agents, the early renal effect parameters retinol-binding protein (RBP) and albumin (ALB) were determined in the urine of 11 hospital workers involved in the preparation and administration of antineoplastic agents and in 23 hospital workers not involved in drug handling, who served as nonexposed controls.
No significant difference was found between the exposed group and the nonexposed control group with respect to the early renal effect parameters RBP and ALB.
Although it was demonstrated that the hospital workers were exposed to cyclophosphamide (CP) and probably other antineo-plastc agents, the results of the present study show that these exposure levels did not cause nephrotoxic effects.
Mots-clés Pascal : Anticancéreux, Exposition professionnelle, Toxicité, Rein pathologie, Personnel sanitaire, Milieu hospitalier, Rétinol, Protéine liaison, Albumine, Homme, Médecine travail, Appareil urinaire pathologie, Protèine RBP
Mots-clés Pascal anglais : Antineoplastic agent, Occupational exposure, Toxicity, Kidney disease, Health staff, Hospital environment, Retinol, Binding protein, Albumin, Human, Occupational medicine, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0173404
Code Inist : 002B02U06. Création : 21/05/1997.