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  1. Preventing hepatitis B in people in close contact with hepatocellular carcinoma patients.

    Article - En anglais

    Objective

    To determine the prevalence of testing for hepatitis B virus (HBV) infection in the clinical management of primary liver cancer (hepatocellular carcinoma).

    Methods

    The authors reviewed the records of 78 patients treated for hepatocellular carcinoma in hospitals in the Puget Sound area in 1988 and early 1989 and reviewed all 1990 U.S. death certificates on which primary liver cancer was listed.

    Results

    The records of 50 (64%) of 78 hepatocellular carcinoma patients contained no evidence that the patient's hepatitis B surface antigen (HBSAg) status had been determined.

    In addition, of 4353 people who died in 1990 for whom the diagnosis of primary liver cancer was listed on the death certificate, HBV infection was also listed for only 136 (3%), much less than expected based on case series.

    Conclusions

    Many patients with hepatocellular carcinoma are not tested for HBV infection, suggesting that their close contacts are also not evaluated for HBV infection and the need for vaccination.

    Hepatitis B vaccination of close personal contacts of HBV-infected hepatocellular carcinoma patients is an important strategy for preventing HBV transmission.

    Mots-clés Pascal : Hépatite virale B, Virose, Infection, Carcinome hépatocellulaire, Sérologie, Contamination, Prévention, Vaccination, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Hepatocellular carcinoma, Serology, Contamination, Prevention, Vaccination, Human, United States, North America, America, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0172532

    Code Inist : 002B05C02G. Création : 21/05/1997.