The relation between estrogen (endogenous and exogenous) and cataract is unclear, with one large population-based study recently suggesting a protective effect of estrogen replacement therapy.
The study reported in this paper, the Blue Mountains Eye Study, was conducted in Australia in 1992-1993 and involved 2,072 women aged 49-97 years.
Subjects were recruited from a defined geographic area ; the participation rate was 83 percent.
Eye examination included photographs of the lens, which were graded for presence and severity of cortical, nuclear, and posterior subcapsular cataracts.
Later age at menarche was associated with increased prevalence of all three types of cataract, but there were no associations with age at menopause, number of children, or use of the oral contraceptive pill.
Among all women, there was no association between hormone replacement therapy and cataract.
However, current users of hormone replacement therapy aged 65 years and over, among whom the duration of use was likely to have been longer than in younger current users, had lower prevalence of cortical cataract than did never users ; the odds ratio adjusted for numerous potential confounders was 0.4 (95 percent confidence interval 0.2-0.8).
The prevalence of posterior subcapsular cataract was increased in current users of hormone replacement therapy who had had a nonsurgical menopause ; the adjusted odds ratio was 2.1 (95 percent confidence interval 1.1-4.1). (...)
Mots-clés Pascal : Cataracte, Ménopause, Oestrogène, Traitement substitutif, Facteur risque, Prévalence, Homme, Epidémiologie, Australie, Océanie, Oeil pathologie, Cristallin pathologie, Segment antérieur pathologie, Hormone
Mots-clés Pascal anglais : Cataract, Menopause, Estrogen, Replacement therapy, Risk factor, Prevalence, Human, Epidemiology, Australia, Oceania, Eye disease, Lens disease, Anterior segment disease, Hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0171651
Code Inist : 002B09G. Création : 21/05/1997.