To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and - negative subjects was determined in a population-based cohort in the Västerbotten county of Northern Sweden.
HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex and area of residence.
The presence of DQAI*0102 was weakly associated with cervical neoplasia in HPVl6-seropositive patients.
DQBI*0602 was weakly associated with disease in all patients, but was strongly increased among HPV16-seropositive patients compared to HPV16-seropositive controls.
DR15 had an association with disease that was particularly strong among HPV16-seropositive subjects.
The haplotype DQAI*0l02-DQBI*0602 (DQ6) was also weakly associated with disease in all patients and significantly increased among HPV16-positive patients when compared to HPV16-positive controls.
A similar association was seen when analysis was restricted to CIN 2-3 patients.
DQAI*0501-DQBI*0301 (DQ7) was more common among HPOV16-negative patients than among HPV16-negative controls and was also more common among HPVI6-negative patients than among HPV16-positive patients.
In conclusion, DQAI*0102-DQBI*0602 (DQ6) is associated with an increased risk of cervical neoplasia among HPV16-seropositive subjects and DQAI*0501-DQBI*0301 (DQ7) with an increased risk among HPV16-seronegative subjects.
Mots-clés Pascal : Dysplasie col utérus, Cancer in situ, Col utérus, Papillomavirus humain 16, Papillomavirus, Papovaviridae, Virus, Homme, Femelle, Réaction chaîne polymérase, Système HLA, Antigène histocompatibilité classe II, Locus HLA-DR, Locus HLA-DQ, Facteur risque, Epidémiologie, Lésion précancéreuse, Appareil génital femelle pathologie, Col utérus pathologie, Biologie moléculaire
Mots-clés Pascal anglais : Cervical dysplasia, Carcinoma in situ, Uterine cervix, Human papillomavirus 16, Papillomavirus, Papovaviridae, Virus, Human, Female, Polymerase chain reaction, HLA-System, Class II histocompatibility antigen, HLA-DR-Locus, HLA-DQ-Locus, Risk factor, Epidemiology, Premalignant lesion, Female genital diseases, Uterine cervix diseases, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0170673
Code Inist : 002B20C02. Création : 21/05/1997.