Concordance in the extent of disease among the family members of patients with Crohn's disease has not been widely investigated.
Furthermore, the relationship between the site of the disease and familial occurrence has never been studied.
Our aim was to evaluate the familial occurrence of Crohn's disease in the various sites.
Nine hundred thirty-four patients with Crohn's disease, observed consecutively in two gastrointestinal departments, were investigated to determine first-degree familial incidence (in both Crohn's disease and ulcerative colitis).
Whenever two or more members were attending the same clinic, only one was regarded as a propositus.
The analysis, therefore, was carried out on 882 patients.
The exact site of the disease was determined in all patients either at diagnosis or during the follow-up by colonoscopy and by small bowel enema.
The rate of concordance in the extent of disease and familial occurrence in the various sites was evaluated and the difference was calculated by chi-square test.
Sixty-one propositi were identified among all the patients.
Forty-nine had familial occurrence for the same disease (concordant patients), whereas 12 had at least one relative with ulcerative colitis (discordant patients).
In 44 propositi with only one relative affected, the rates of concordance in the extent of the disease were 84,68,18, and 0% respectively, for the ileum, the ileum-right colon, the ileum-total colon, and the colon. (...)
Mots-clés Pascal : Entérite Crohn, Relation, Localisation, Déterminisme génétique, Maladie héréditaire, Facteur risque, Etude statistique, Homme, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Génétique, Maladie congénitale
Mots-clés Pascal anglais : Crohn disease, Relation, Localization, Genetic inheritance, Genetic disease, Risk factor, Statistical study, Human, Digestive diseases, Intestinal disease, Inflammatory disease, Genetics, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0167622
Code Inist : 002B13B03. Création : 21/05/1997.