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  1. Integrated Exposure and Dose Modeling and Analysis System. 1. Formulation and testing of microenvironmental and pharmacokinetic components.

    Article - En anglais

    The conceptual and theoretical framework for a modular integrated Exposure and Dose Modeling and Analysis System (EDMAS) has been formulated, and its stepwise implementation and testing is currently in progress.

    This system aims to provide state-of-the-arttools for performing integrated assessments of exposure and dose for individuals and populations.

    The integration of modeling components with each other as well as with available environmental, exposure, and toxicological databases is being accomplished with the use of computational tools that include interactive simulation environments, Geographical Information Systems, and various data retrieval, management, statistical analysis, and visualization methods.

    This paper overviews the structure and modular nature of this integrated modeling system and focuses specifically on two of its components : (a) a hierarchy of physiologically based pharmacokinetic models (PBPKM), representing various levels of detail and sophistication, and (b) a family of microenvironmental models, that incorporate complex physical and chemical transformations.

    The deterministic implementation of these components is also presented here in two test applications : (i) a case study of benzene exposure indoors resulting from the volatilization of contaminated tap water and (ii) a case study of photochemical pollution infiltration indoors, in an office building environment.

    Mots-clés Pascal : Pollution, Environnement, Exposition, Homme, Evaluation, Toxique, Composé chimique, Modélisation, Modèle PBPK, Santé et environnement, Article synthèse, Méthode étude, Système intégré, Benzène, Pollution intérieur, Microenvironnement

    Mots-clés Pascal anglais : Pollution, Environment, Exposure, Human, Evaluation, Poison, Chemical compound, Modeling, Physiologically based pharmacokinetic model, Health and environment, Review, Investigation method, Integrated system, Benzene, Indoor pollution

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0160007

    Code Inist : 002B03M01. Création : 21/05/1997.