logo BDSP

Base documentaire

  1. Adverse drug events in hospitalized patients : Excess length of stay, extra costs, and attributable mortality.

    Article - En anglais


    - To determine the excess length of stay, extra costs, and mortality attributable to adverse drug events (ADEs) in hospitalized patients.


    - Matched case-control study.


    - The LDS Hospital, a tertiary care health care institution.


    - All patients admitted to LDS Hospital from January 1,1990, to December 31,1993, were eligible.

    Cases were defined as patients with ADEs that occurred during hospitalization ; controls were selected according to matching variables in a stepwise fashion.


    - Controls were matched to cases on primary discharge diagnosis related group (DRG), age, sex, acuity, and year of admission ; varying numbers of controls were matched to each case.

    Matching was successful for 71% of the cases, leading to 1580 cases and 20197 controls.

    Main Outcome Measures

    - Crude and attributable mortality, crude and attributable length of stay, and cost of hospitalization.


    - ADEs complicated 2.43 per 100 admissions to the LDS Hospital during the study period.

    The crude mortality rates for the cases and matched controls were 3.5% and 1.05%, respectively (P<. 001).

    The mean length of hospital stay significantly differed between the cases and matched controls (7.69 vs 4.46 days ; P<. 001) as did the mean cost of hospitalization ($10 010 vs $5355 ; P<. 001).

    The extra length of hospital stay attributable to an ADE was 1.74 days (P<. 001).

    The excess cost of hospitalization attributable to an ADE was $2013 (P<. 001). (...)

    Mots-clés Pascal : Toxicité, Médicament, Analyse coût, Mortalité, Durée, Hospitalisation, Economie santé, Homme, Hôpital

    Mots-clés Pascal anglais : Toxicity, Drug, Cost analysis, Mortality, Duration, Hospitalization, Health economy, Human, Hospital

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0156019

    Code Inist : 002B02W. Création : 21/05/1997.