Collagenous colitis : a retrospective study of clinical presentation and treatment in 163 patients.
Background-Data on collagenous colitis have been based on a limited number of patients.
Aims-To obtain more information on this disease from a register set up at Orebro Medical Center Hospital.
Patients and methods-Twenty five Swedish hospitals have contributed to this patient register, which comprises 163 histopathologically verified cases.
Clinical data were retrospectively analysed
Collagenous colitis followed a chronic intermittent course in most cases (85%) with a sudden onset in 42%. Symptoms were chronic watery diarrhoea, often nocturnal (27%), abdominal pain (41%), and weight loss (42%). Sixty six patients (40%) had one or more associated diseases.
Routine laboratory data were mostly normal
The median age at diagnosis was 55 (range 16-86) years, but 25% of the patients were younger than 45 years.
Seven patients died of unrelated diseases
The response rate for sulphasalazine was 59%, and 50% and 40% for mesalazine and olsalazine.
Prednisolone was most effective with a response rate of 82%, but the required dose was often high and the effect was not sustained after withdrawal.
Antibiotics were efficient in 63%. Cholestyramine and loperamide had response rates of 59% and 71% respectively.
Conclusions-Collagenous colitis follows a chronic continuous course.
Symptoms can be socially disabling, but the disease does not seem to have a malignant potential.
A plan for the treatment of a newly diagnosed patient with collagenous colitis is proposed.
Mots-clés Pascal : Colite collagène, Pathogénie, Symptomatologie, Facteur risque, Transformation maligne, Diagnostic, Traitement, Protocole thérapeutique, Résultat, Homme, Appareil digestif pathologie, Intestin pathologie, Epidémiologie
Mots-clés Pascal anglais : Collagenous colitis, Pathogenesis, Symptomatology, Risk factor, Malignant transformation, Diagnosis, Treatment, Therapeutic protocol, Result, Human, Digestive diseases, Intestinal disease, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0155955
Code Inist : 002B13B03. Création : 21/05/1997.