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  1. Collagenous colitis : a retrospective study of clinical presentation and treatment in 163 patients.

    Article - En anglais

    Background-Data on collagenous colitis have been based on a limited number of patients.

    Aims-To obtain more information on this disease from a register set up at Orebro Medical Center Hospital.

    Patients and methods-Twenty five Swedish hospitals have contributed to this patient register, which comprises 163 histopathologically verified cases.

    Clinical data were retrospectively analysed

    Results

    Collagenous colitis followed a chronic intermittent course in most cases (85%) with a sudden onset in 42%. Symptoms were chronic watery diarrhoea, often nocturnal (27%), abdominal pain (41%), and weight loss (42%). Sixty six patients (40%) had one or more associated diseases.

    Routine laboratory data were mostly normal

    The median age at diagnosis was 55 (range 16-86) years, but 25% of the patients were younger than 45 years.

    Seven patients died of unrelated diseases

    The response rate for sulphasalazine was 59%, and 50% and 40% for mesalazine and olsalazine.

    Prednisolone was most effective with a response rate of 82%, but the required dose was often high and the effect was not sustained after withdrawal.

    Antibiotics were efficient in 63%. Cholestyramine and loperamide had response rates of 59% and 71% respectively.

    Conclusions-Collagenous colitis follows a chronic continuous course.

    Symptoms can be socially disabling, but the disease does not seem to have a malignant potential.

    A plan for the treatment of a newly diagnosed patient with collagenous colitis is proposed.

    Mots-clés Pascal : Colite collagène, Pathogénie, Symptomatologie, Facteur risque, Transformation maligne, Diagnostic, Traitement, Protocole thérapeutique, Résultat, Homme, Appareil digestif pathologie, Intestin pathologie, Epidémiologie

    Mots-clés Pascal anglais : Collagenous colitis, Pathogenesis, Symptomatology, Risk factor, Malignant transformation, Diagnosis, Treatment, Therapeutic protocol, Result, Human, Digestive diseases, Intestinal disease, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0155955

    Code Inist : 002B13B03. Création : 21/05/1997.