To investigate the prevalence and extent of cerebral changes in patients with systemic lupus erythematosus (SLE) by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).
SLE patients (47 women) and controls (25 women) underwent 1.5T MRI.
A semiautomated segmentation technique calculated cerebrospinal fluid (CSF) and brain volumes.
Proton MRS of the frontal and parieto-occipital white matter yielded metabolite ratios of N-acetyl groups (NA), choline, and creatine.
Compared with the control group, the SLE patients more often had cerebral atrophy on MRI (32% versus 0%), confirmed by an increase in the CSF to intracranial volume ratio.
The patients also had old infarcts and hemorrhages (8.5% versus 0%) and more small white matter lesions (23% versus 8% had>5 such lesions).
MRS showed relative reduction of NA peaks.
Although no patient was studied when acutely ill, prior neurologic involvement was related to abnormal findings.
MRI and MRS are helpful in the investigation of cerebral complications of SLE.
There are chronic changes which may be ischemic in nature.
Their precise cause, consequences, and prevention are current challenges.
Mots-clés Pascal : Lupus érythémateux, Disséminé, Homme, Encéphale pathologie, Complication, Imagerie RMN, Spectrométrie RMN, Prévalence, Epidémiologie, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Système nerveux pathologie, Système nerveux central pathologie, Imagerie médicale
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Human, Cerebral disorder, Complication, Nuclear magnetic resonance imaging, NMR spectrometry, Prevalence, Epidemiology, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Nervous system diseases, Central nervous system disease, Medical imagery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0151240
Code Inist : 002B07. Création : 21/05/1997.