Translating clinical trials to clinical practice. Satellite symposium. Glasgow (GBR), 1994/11/29.
To describe the treatment patterns for intravenous ganciclovir induction and maintenance therapy in AIDS patients with cytomegalovirus (CMV) retinitis in five European countries and to investigate the anticipated impact of oral ganciclovir on resource utilization during maintenance.
Study was a retrospective analysis based on a prospective randomized clinical trial (AV1034) comparing the efficacy of oral versus intravenous ganciclovir in CMV retinitis maintenance therapy.
Resource utilization patterns for ganciclovir induction and maintenance, retinitis progression and management and treatment of adverse events were based on clinical trial data and interviews with local experts involved in treatment of patients with CMV retinitis.
Oral ganciclovir maintenance was effective, although associated with a faster time to progression, compared to intravenous ganciclovir.
There was considerable variation in the treatment patterns for induction with intravenous ganciclovir in the different countries.
Most inductions were achieved with a central intravenous line, also used in subsequent intravenous maintenance therapy, usually performed on an outpatient or day care inpatient basis.
Intravenous maintenance therapy was identified as a large resource utilization which would decrease considerably with the introduction of oral ganciclovir. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Association, Rétinite, Cytomegalovirus humain, Betaherpesvirinae, Herpesviridae, Virus, Traitement, Ganciclovir, Antiviral, Chimiothérapie, Maintenance, Voie orale, Voie intraveineuse, Coût, Essai clinique, Europe, Etude multicentrique, Homme, Nucléoside acyclique, Purine nucléoside, Immunopathologie, Immunodéficit, Economie santé, Oeil pathologie, Rétinopathie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Association, Retinitis, Human cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, Treatment, Ganciclovir, Antiviral, Chemotherapy, Maintenance, Oral administration, Intravenous administration, Costs, Clinical trial, Europe, Multicenter study, Human, Acyclic nucleoside, Purine nucleoside, Immunopathology, Immune deficiency, Health economy, Eye disease, Retinopathy
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0150776
Code Inist : 002B05C02B. Création : 21/05/1997.