Chronic HCV Infection : Public Health Threat and Emerging Consensus. Symposium. Vienna (AUT), 1995/10/27.
Hepatitis C virus (HCV) infection appears to have a slow but progressive evolution to chronic hepatitis and cirrhosis in a significant percentage of patients.
Chronic hepatitis develops in 60-80% of patients.
Worldwide prospective studies have shown that a further 20-30% of patients with chronic active hepatitis will develop cirrhosis regardless of the possible source of HCV infection.
The percentage of cirrhotics is generally believed to increase progressively as the length of follow-up increases.
In patients with chronic HCV, there also is high risk for the development of hepatocellular carcinoma.
Factors influencing the rate of progression from chronic hepatitis to cirrhosis appear to include age at time of exposure, duration of infection, degree of liver damage at initial biopsy, immunological status, and possibly HCV genotype.
The mean intervals between the time of initial infection and the diagnosis of chronic hepatitis, cirrhosis, and hepatocellular carcinoma have been estimated to be 10,20, and 30 years, respectively.
The progression of disease is variable and is not always orderly and sequential.
Patients can progress from chronic persistent hepatitis or chronic active hepatitis directly to hepatocellular carcinoma without first developing cirrhosis, especially those with genotype 1b.
In addition, cirrhosis does not appear to lead to clinically apparent hepatic failure in all patients. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Evolution, Chronique, Facteur risque, Complication, Cirrhose, Foie, Carcinome hépatocellulaire, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Evolution, Chronic, Risk factor, Complication, Cirrhosis, Liver, Hepatocellular carcinoma, Statistical study, Human, Digestive diseases, Hepatic disease, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0148091
Code Inist : 002B05C02G. Création : 21/05/1997.