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  1. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome.

    Article - En anglais

    Institutionalized patients with Down syndrome (n=307) were monitored for 5 to 10 years prospectively to determine prevalence of Alzheimer-type dementia.

    Clinical signs, cognitive functioning, and EEGs were assessed.

    When possible, postmortem neuropathological examinations were conducted.

    Progressive mental and physical deterioration was found for 56 of the residents.

    Mean age at onset of dementia was 56 years.

    Prevalence increased from 11% between ages 40 and 49 to 77% between 60 and 69.

    All patients 70 and over had dementia.

    Neuropathological findings were consistent with clinical diagnosis.

    Use of a dementia checklist, cognitive skills inventory, and EEG reliably detected Alzheimer-type dementia at an earlv stage.

    Mots-clés Pascal : Association morbide, Démence Alzheimer, Arriération mentale, Trouble développement, Trisomie, Aneuploïdie, Aberration chromosomique, Chromosome G21, Mongolisme, Prévalence, Epidémiologie, Adulte jeune, Homme, Adulte, Vieillard, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Concomitant disease, Alzheimer disease, Mental retardation, Developmental disorder, Trisomy, Aneuploidy, Chromosomal aberration, Chromosome G21, Down syndrome, Prevalence, Epidemiology, Young adult, Human, Adult, Elderly, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0147343

    Code Inist : 002B18C12. Création : 21/05/1997.