Immunomodulatory effects of occupational exposure to mancozeb.
The effects of occupational exposure to ethylene-bis-dithiocarbamate of manganese and zinc on the immune system were evaluated in a group of mancozeb-exposed manufacturers and controls.
The immune system tests revealed the following :
(a) lymphocyte proliferative responses triggered by different activators and mitogen-induced IL-2 production were higher in exposed subjects than in controls ;
(b) production of monocyte/macrophage-derived IL-1 and polyclonal IgG and IgM, by bêta-lymphocytes, did not differ between exposed subjects and controls ;
(c) percentages and absolute numbers of total T-cells,
T-suppressor/cytotoxic cells, activated T-cells, total bêta-cells, and natural killer cells were similar in exposed subjects and controls ;
(d) serum immunoglobulin classes and complement fractions were within the range of normality ;
and (e) rheumatoid factor and non-organ-specific serum autoantibodies were absent in exposed and control subjects.
An increase in T-cell functional response was found in the exposed group, suggesting a slight immunomodulator effect of mancozeb in conditions of low-level, prolonged occupational exposure.
Mots-clés Pascal : Fongicide, Pesticide, Exposition professionnelle, Dithiocarbamate organique, Toxicité, Homme, Système immunitaire, Exploration immunologique, In vivo, In vitro, Lymphocyte, Médecine travail, Carbamate, Mancozeb
Mots-clés Pascal anglais : Fungicide, Pesticides, Occupational exposure, Organic dithiocarbamate, Toxicity, Human, Immune system, Immunological investigation, In vivo, In vitro, Lymphocyte, Occupational medicine, Carbamate
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0144264
Code Inist : 002B03G. Création : 21/05/1997.