We examined the relationships of whole blood viscosity and its major determinants to incident cardiovascular events (ischaemic heart disease and stroke) in a prospective study of a random population sample of 1592 men and women aged 55-74 years (the Edinburgh Artery Study). 272 fatal and non-fatal cardiovascular events occurred during 5 years of follow-up (cumulative incidence 17.1%). Age and sex adjusted mean levels of blood viscosity (3.70 v 3.55mPa. s), haematocrit (46.2 v 45.7%), haematocrit-corrected blood viscosity (3.57 v 3.48 mPa. s), plasma viscosity (1.35 v 1.33mPa. s) and fibrinogen (2.88 v 2.67 g/l) were significantly higher in subjects who experienced events than in subjects who did not.
The relationships of these rheological variables to cardiovascular events were at least as strong as those of conventional risk factors (smoking habit, diastolic blood pressure, and low-density lipoprotein cholesterol).
After adjustment for these conventional risk factors, the associations of blood viscosity and haematocrit remained significant for stroke, but not for total events ; whereas the associations of plasma viscosity and fibrinogen remained significant for total events and for stroke.
These findings suggest that increased blood viscosity may be one plausible biological mechanism through which increases in haematocrit and fibrinogen may promote ischaemic heart disease and stroke. (...)
Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Epidémiologie, Accident cérébrovasculaire, Viscosité, Sang, Hématocrite, Fibrinogène, Facteur coagulation, Rhéologie, Ecosse, Grande Bretagne, Royaume Uni, Europe, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Epidemiology, Stroke, Viscosity, Blood, Hematocrite, Fibrinogen, Coagulation factor, Rheology, Scotland, Great Britain, United Kingdom, Europe, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0137779
Code Inist : 002B12A03. Création : 21/05/1997.