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  1. The importance of comorbidity in HIV-infected patients over 55 : A retrospective case-control study.

    Article - En anglais


    To study the impact of comorbidity on the course of HIV disease in older patients as compared to a matched cohort of younger patients.


    In a retrospective case-control study, we compared 43 HIV-infected patients>55 years old to a randomly selected cohort of 86 patients<45 years old, matched by date of HIV diagnosis.

    We collected data on non-HIV-related morbidity (as assessed by the Charlson comorbidity index), initiator of HIV testing, HIV stage at time of HIV diagnosis (TOHD), AIDS defining diagnoses, AIDS-related illnesses (ARI), observed AIDS-free interval, survival, and frequency of HIV-related and unrelated hospitalizations.


    The older cohort was more likely to have had HIV testing initiated by a heath care provider (36 of 36 versus 50 of 66, P=0.003), and to have acquired HIV from a transfusion (5 of 43 versus 0 of 86, P=0.001), had lower CD4 cell counts at TOHD (205 versus 429, P=0.02), a shorter observed AIDS-free interval (24.0 versus 52.8 months, P=0.0002) and a shorter survival (28.2 versus 58.9 months, P=0.0002).

    The older cohort had more HIV-related (13.4 versus 9.2 per 100 patient-months, P=0.024) and non-HIV-related hospitalizations (12.9 versus 8.1 per 100 patient-months, P=0.0001).

    The comorbidity index was significantly higher in the older cohort (0.907 versus 0.198, P=0.0001) and was a strong predictor of mortality, independent of age group (risk ratio=1.38 per comorbidity point, P=0.0003). (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Age, Morbidité, Association, Etude comparative, Mortalité, Adulte jeune, Homme, Adulte, Epidémiologie, Rétrospective, Etude cas témoin, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Age, Morbidity, Association, Comparative study, Mortality, Young adult, Human, Adult, Epidemiology, Retrospective, Case control study, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0137232

    Code Inist : 002B06D01. Création : 21/05/1997.