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  1. Non-traditional risk factors for atherosclerosis in high risk children.

    Article - En anglais

    Non-traditional risk factors for atherosclerosis were examined in children whose fathers suffered from myocardial infarction up to age 48.

    Factors examined were hyperinsulinemia, insulin resistance, lipoprotein (a) [Lp (a) ], fibrinogen, cardiovascular hyperreactivity, and autonomic nervous system dysfunction.

    Hyperinsulinemia was present in five cases (9%) and hypoinsulinemia in two.

    Insulin output following glucose load was significantly higher in obese children compared with controls.

    There was an increase in Lp (a) alone in 14 cases (24%) and with low density lipoprotein in 6 cases.

    Increased fibrinogen and positive correlation with insulin abnormality was present in 29% (76% females) (P>0.02).

    Cardiac hyperreactivity (increased systolic blood pressure) was present in 9% and increased blood pressure and pulse rate in 17%. Holter monitoring pattern was sympathetic in 39% and parasympathetic in 47% of cases.

    Thus a number of non-traditional risk factors were found to be higher than normal in a relatively large number of children at high risk for atherosclerosis, with 25 children having more than three risk factors.

    Mots-clés Pascal : Athérosclérose, Epidémiologie, Facteur risque, Adolescent, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Atherosclerosis, Epidemiology, Risk factor, Adolescent, Human, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0136400

    Code Inist : 002B12B01. Création : 21/05/1997.