Non-traditional risk factors for atherosclerosis were examined in children whose fathers suffered from myocardial infarction up to age 48.
Factors examined were hyperinsulinemia, insulin resistance, lipoprotein (a) [Lp (a) ], fibrinogen, cardiovascular hyperreactivity, and autonomic nervous system dysfunction.
Hyperinsulinemia was present in five cases (9%) and hypoinsulinemia in two.
Insulin output following glucose load was significantly higher in obese children compared with controls.
There was an increase in Lp (a) alone in 14 cases (24%) and with low density lipoprotein in 6 cases.
Increased fibrinogen and positive correlation with insulin abnormality was present in 29% (76% females) (P>0.02).
Cardiac hyperreactivity (increased systolic blood pressure) was present in 9% and increased blood pressure and pulse rate in 17%. Holter monitoring pattern was sympathetic in 39% and parasympathetic in 47% of cases.
Thus a number of non-traditional risk factors were found to be higher than normal in a relatively large number of children at high risk for atherosclerosis, with 25 children having more than three risk factors.
Mots-clés Pascal : Athérosclérose, Epidémiologie, Facteur risque, Adolescent, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Atherosclerosis, Epidemiology, Risk factor, Adolescent, Human, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0136400
Code Inist : 002B12B01. Création : 21/05/1997.