Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa.
The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity.
Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma, and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992.
All participants were between the ages of 55 and 69 and held a valid Iowa driver's license.
A total of 472 women in the cohort (1.35%) reported a history of SLS at baseline.
Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa.
Data were analyzed using Cox proportional hazards regression.
During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS.
Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI).
Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P<0.01), they were not more likely to develop breast carcinoma (relative risk [RR]=1.2 ; 95% confidence interval [CI]=0.7-2). (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Postménopause, Ovaire polykystique, Epidémiologie, Prospective, Incidence, Etude cohorte, Iowa, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Glande mammaire pathologie, Appareil génital femelle pathologie, Ovaire pathologie, Stérilité femelle, Tumeur bénigne, Kyste
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Postmenopause, Polycystic ovary, Epidemiology, Prospective, Incidence, Cohort study, Iowa, United States, North America, America, Human, Malignant tumor, Mammary gland diseases, Female genital diseases, Ovarian diseases, Female sterility, Benign neoplasm, Cyst
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0134166
Code Inist : 002B20E02. Création : 21/05/1997.