Atherosclerosis and thrombosis may lead to cognitive impairment through cerebral infarcts or white matter hyperintensities.
Oxidative stress is now seen as a major contributor to the process of atherogenesis.
High intake of polyunsaturated fatty acids, e.g., linoleic acid, or low intake of antioxidants can increase oxidative stress.
High intake of n-3 polyunsaturated fatty acids and its main source, fish, may reduce the risk of thrombosis.
Little is known, however, about the relation between these dietary factors and cognitive function.
The authors investigated this relation with data derived from a cohort of men, aged 69-89 years, who were participants in the Zutphen Elderly Study.
The 30-point Mini-Mental State Examination was used to assess cognitive impairment in 1990 (score ¾25 in 153/476 men, 32%) and cognitive decline from 1990 to 1993 (drop>2 points in 51/342 men, 15%). Food intake was estimated in 1985 and 1990 by the cross-check dietary history method.
High linoleic acid intake was associated with cognitive impairment after adjustment for age, education, cigarette smoking, alcohol consumption, and energy intake (odds ratio (OR) for highest vs. lowest tertile=1.76,95% confidence interval (CI) 1.04-3.01).
Intake of n-3 polyunsaturated fatty acids was not associated with cognitive impairment, whereas high fish consumption tended to be inversely associated with cognitive impairment (OR=0.63,95% CI 0.33-1.21) and cognitive decline (OR=0.45,95% CI 0.17-1.16). (...)
Mots-clés Pascal : Acide gras polyinsaturé, Antioxydant, Cognition, Consommation alimentaire, Régime alimentaire, Pisces, Vertebrata, Linoléique acide, Epidémiologie, Vieillard, Homme, Pays Bas, Europe
Mots-clés Pascal anglais : Polyunsaturated fatty acid, Antioxidant, Cognition, Food intake, Diet, Pisces, Vertebrata, Linoleic acid, Epidemiology, Elderly, Human, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0133242
Code Inist : 002B30A02A. Création : 21/05/1997.