Fasting insulin level underestimates risk of non-insulin-dependent diabetes mellitus due to confounding by insulin secretion.
Fasting insulin has been used as a surrogate measure of insulin sensitivity in studies of non-insulin-dependent diabetes mellitus (NIDDM) risk, but the fasting insulin-NIDDM association may be confounded by insulin secretion, which correlates negatively with NIDDM risk and positively with fasting insulin level.
In a prospective 5-year study of 137 nondiabetic Japanese-American men in King County, Washington State, higher fasting insulin was not strongly related to NIDDM (odds ratio (OR)=1.37,95% confidence interval (CI) 0.80-2.34), but this odds ratio increased substantially after adjustment for insulin secretion (OR=2.92,95% CI 1.41-6.06).
Research on NIDDM risk in relation to fasting insulin may yield biased effect measures unless adjusted for insulin secretion.
Mots-clés Pascal : Diabète non insulinodépendant, Insuline, Sécrétion, Jeûne alimentaire, Peptide C, Epidémiologie, Risque, Taux, Homme, Etats Unis, Amérique du Nord, Amérique, Prospective, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Insulin, Secretion, Fasting, C-Peptide, Epidemiology, Risk, Rate, Human, United States, North America, America, Prospective, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0133072
Code Inist : 002B21E01A. Création : 21/05/1997.