Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population : The Rotterdam Study.
To estimate the prevalence of glucose intolerance in the elderly, oral glucose tolerance tests were performed as part of the Rotterdam Study, a population-based study in subjects aged 55 years and over.
The study population consisted of 2,668 men and 3,950 women.
Diabetes mellitus was defined as the use of antidiabetes medication, or a random or post-load serum glucose level of =11.1 mmol/liter.
Impaired glucose tolerance was defined as a post-load serum glucose between 7.8 and 11.1 mmol/liter.
In men, the frequency of diabetes mellitus ranged from 5.9% in ages<60 years to 19.8% in ages>85 years, and in women from 3.8% in ages<60 years to 18.9% in ages>85 years ; more than half of the subjects with diabetes were newly diagnosed.
The prevalence of impaired glucose tolerance ranged from 8.8% and 11.0% in men and women aged<60 years to 24.3% and 34.7% in men and women aged>85 years.
The prevalence of diabetes mellitus in the total Rotterdam Study population of 7,439 elderly men and women was estimated to be 11.3% (95% confidence interval (CI) 10.5-12.0).
Waist/hip ratio, systolic blood pressure, hypertension, and number of cigarettes smoked increased with a worsening of the glucose tolerance from normal, hyperinsulinemia, impaired glucose tolerance to diabetes in both men and women (p<0.01, adjusted for age).
Body mass index was higher in subjects with glucose intolerance, but the frequency of obesity showed a relative decrease with worsening of glucose tolerance. (...)
Mots-clés Pascal : Diabète, Anomalie tolérance glucose, Hyperinsulinémie, Obésité, Tabagisme, Hyperlipémie, Hypertension artérielle, Epidémiologie, Prévalence, Association, Facteur risque, Vieillard, Homme, Adulte, Pays Bas, Europe, Endocrinopathie
Mots-clés Pascal anglais : Diabetes mellitus, Impaired glucose tolerance, Hyperinsulinemia, Obesity, Tobacco smoking, Hyperlipemia, Hypertension, Epidemiology, Prevalence, Association, Risk factor, Elderly, Human, Adult, Netherlands, Europe, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0132434
Code Inist : 002B21E01A. Création : 21/05/1997.