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  1. Reliability of data from proxy respondents in an international case-control study of cardiovascular disease and oral contraceptives.

    Article - En anglais

    Study objectives

    To evaluate the reliability of data supplied in a case-control study by proxy respondents for cases who were too ill to do so themselves.


    A hospital based, case-control study of the current use of oral contraceptives (OC) and cardiovascular diseases.

    Data from « true 

    » controls matched to a subset of cases were compared with those supplied by proxy respondents about the true controls.


    Hospitals in 21 centres from Africa, Asia, Europe, and Latin America.

    Patients and participants

    For a subset of cases, 403 pairs of controls - one « true » and one proxy - were interviewed. « True » controls were matched by age, place, and time of admission and were admitted with 1 of 27 permissible diagnoses not associated with OC use.

    Proxy controls were either relatives or friends of true controls.

    Main results

    Levels of concordance between data from proxy and true controls were high for most variables regarding recent events, including current OC use, but were greatly diminished when detailed information, particularly from the past, was required.

    Husbands were usually the best proxy, although this was question-specific.

    The sensitivity and specificity of proxy responses were 93% (95% confidence intervals : 77%, 99%) and 100% (98%, 100%) respectively, for current use of OC. (...)

    Mots-clés Pascal : Fiabilité, Donnée, Réponse, Milieu familial, Conjoint, Environnement social, Appareil circulatoire pathologie, Contraception, Voie orale, Contraceptif, Méthodologie, Evaluation performance, Homme, Epidémiologie, Etude comparative, International, Etude en condition contrôlée, Ami

    Mots-clés Pascal anglais : Reliability, Data, Response, Family environment, Spouse, Social environment, Cardiovascular disease, Contraception, Oral administration, Contraceptive, Methodology, Performance evaluation, Human, Epidemiology, Comparative study, International, Controlled environment study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0132128

    Code Inist : 002B30A01A1. Création : 21/05/1997.