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  1. Chemoprevention of colorectal cancer.

    Article - En anglais

    This review summarizes the principles of cancer chemoprevention and discusses the evidence from epidemiologic and experimental studies and preclinical and clinical trials of potential colorectal chemopreventive agents.

    The putative mechanisms of action of the drugs in chemoprevention and their potential to reduce the incidence and mortality rate of colorectal neoplasms are discussed.

    The future of colorectal chemoprevention will depend on important new insights into molecular carcinogenesis of colorectal cancer, application of molecular markers as surrogate endpoints, and ultimately on therapeutic targets of prevention in clinical trials.

    Mots-clés Pascal : Carcinome, Côlon, Rectum, Dépistage, Marqueur biologique, Protection chimique, Chimiothérapie, Antiinflammatoire non stéroïde, Calcium, Antioxydant, Vitamine, Alimentation, Mécanisme action, Animal, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Medical screening, Biological marker, Chemical protection, Chemotherapy, Non steroidal antiinflammatory agent, Calcium, Antioxidant, Vitamin, Feeding, Mechanism of action, Animal, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0131867

    Code Inist : 002B13B01. Création : 21/05/1997.