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  1. Haemostatic variables in Pacific Islanders apparently free from stroke and ischaemic heart disease : The kitava study.

    Article - En anglais

    We cross-sectionally measured plasminogen activator inhibitor-1 (PAI-1) activity, fibrinogen, factor VII (FVII : C) and VIII (FVIII : C) coagulant activity, and von Willebrand factor antigen (VWF : Ag) in 162 traditional horticulturalists older than 40 years from the tropical island of Kitava, Papua New Guinea, where the intake of western food is negligible and where stroke and ischaemic heart disease appear to be absent.

    Identical analyses were made in Swedish subjects of comparable ages.

    Kitavans had markedly lower PAI-1 activity, with 85% of males and 100% of females having PAI-I activity ¾5 U/ml, as compared with 22 and 14% in Swedish males and females (p<0.0001).

    Surprisingly, Kitavans also had higher FVII : C, FVIII : C and VWF : Ag.

    Fibrinogen was 10% lower in Kitavan males while 25% higher in Kitavan females.

    The very low PAI-I activity in Kitavans may explain some of their apparent freedom from cardiovascular disease and probably relates to their extreme leanness.

    Mots-clés Pascal : Cardiopathie coronaire, Accident cérébrovasculaire, Facteur risque, Epidémiologie, Papouasie Nouvelle Guinée, Mélanésie, Océanie, Fibrinogène, Facteur coagulation, Facteur VIII procoagulant, Facteur Willebrand, Proconvertine, Coagulation sanguine, Homme, Appareil circulatoire pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Vaisseau sanguin pathologie, Inhibiteur plasminogen activator 1

    Mots-clés Pascal anglais : Coronary heart disease, Stroke, Risk factor, Epidemiology, Papua New Guinea, Melanesia, Oceania, Fibrinogen, Coagulation factor, Factor VIIIc, Willebrand factor, Factor VII, Blood coagulation, Human, Cardiovascular disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Vascular disease, Plasminogen activator inhibitor 1

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0130463

    Code Inist : 002B12A03. Création : 21/05/1997.