Objectives-To test whether dioxins affect liver and thyroid function, lipid metabolism and glucose or immunological variables, in workers exposed to brominated dioxins and furans.
Methods-34 male production employees (29 were extruder operators) and eight technical support personnel were studied, all of whom were potentially exposed to polybrominated dibenzo-p-dioxins (PBDDs) and furans (PBDFs) during production of resins containing polybrominated diphenyl ethers (PBDEs).
Controls were from a similar resin producing plant that did not use PBDEs.
Blood samples were analysed for tetra, penta, and hexabrominated congeners, but 2,3,7,8-TBDD was the only exposure measure used in the regression analyses.
Seven liver function indicators, five measures of blood lipids and glucose, four haematology and blood coagulation measures, and three measures of thyroid function were examined.
None of the variables was statistically related to concentration of 2,3,7,8-TBDD in the regression analyses.
Cigarette smoking was related to several outcomes at the 0.05 level : aspartate aminotransferase, alanine aminotransferase, glutamate dehydrogenase (GLDH), erythrocyte sedimentation rate, and white blood cell count.
Body mass index was also related to alanine aminotransferase, gamma-glutamyltranspeptidase, cholinesterase, GLDH, cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, and glucose concentrations. (...)
Mots-clés Pascal : Dibenzofurane, Brome Composé organique, Exposition professionnelle, Toxicité, Homme, Foie, Thyroïde, Métabolisme, Lipide, Glucose, Hématologie, Presse extrusion, Médecine travail, Dibenzo-p-dioxine(polybromo)
Mots-clés Pascal anglais : Bromine Organic compounds, Occupational exposure, Toxicity, Human, Liver, Thyroid gland, Metabolism, Lipids, Glucose, Hematology, Extruder, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0126376
Code Inist : 002B03L06. Création : 21/05/1997.