Incidence of childhood leukaemia and non-Hodgkin's lymphoma in the vicinity of nuclear sites in Scotland, 1968-93.
Objectives-The primary aims were to investigate the incidence of leukaemia and non-Hodgkin's lymphoma in children resident near seven nuclear sites in Scotland and to determine whether there was any evidence of a gradient in risk with distance of residence from a nuclear site.
A secondary aim was to assess the power of statistical tests for increased risk of disease near a point source when applied in the context of census data for Scotland.
Methods-The study data set comprised 1287 cases of leukaemia and non-Hodgkin's lymphoma diagnosed in children aged under 15 years in the period 1968-93, validated for accuracy and completeness.
A study zone around each nuclear site was constructed from enumeration districts within 25 km.
Expected numbers were calculated, adjusting for sex, age, and indices of deprivation and urban-rural residence.
Six statistical tests were evaluated.
Stone's maximum likelihood ratio (unconditional application) was applied as the main test for general increased incidence across a study zone.
The linear risk score based on enumeration districts (conditional application) was used as a secondary test for declining risk with distance from each site.
More cases were observed (O) than expected (E) in the study zones around Rosyth naval base (O/E 1.02), Chapelcross electricity generating station (O/E 1.08), and Dounreay reprocessing plant (O/E 1.99).
The maximum likelihood ratio test reached significance only for Dounreay (P=0.030). (...)
Mots-clés Pascal : Leucémie, Enfant, Homme, Lymphome non hodgkinien, Epidémiologie, Incidence, Proximité, Centrale nucléaire, Zone résidentielle, Ecosse, Grande Bretagne, Royaume Uni, Europe, Radiocontamination, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Leukemia, Child, Human, Non Hodgkin lymphoma, Epidemiology, Incidence, Proximity, Nuclear power plant, Residential zone, Scotland, Great Britain, United Kingdom, Europe, Radioactive contamination, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0126372
Code Inist : 002B19B. Création : 21/05/1997.