Relation of spirometric function to radiographic interstitial fibrosis in two large workforces exposed to asbestos : an evaluation of the ILO profusion score.
Objectives-To analyse quantitatively the relations of spirometric lung function (forced vital capacity (FVC)) to radiographic interstitial pulmonary fibrosis (assessed by the International Labour Organisation (ILO) profusion score of small irregular opacities) in two large workforces exposed to different intensities of asbestos.
These analyses consider the question whether a similar profusion score in differently exposed workers is associated with a similar effect on lung function.
Methods-Surveys of two workforces, insulators (n=2611) and sheet metal workers (n=1245), by the same investigators allowed comparison of the effects of the two levels of exposure to asbestos.
The two groups were of similar age and had similar percentages of non-smokers and smokers.
All radiographs were read by the same expert reader.
Consistent with their less continuous and less intense exposure to asbestos, metal workers had :
(a) far less frequent radiographic asbestosis (profusion score = 1/0,17.5% v 59.6% for insulators) ;
(b) less severe radiographic asbestosis (only 1.1% had scores = 2/1 v 13.3% of insulators) ;
(c) a similar slope to that seen in insulators for the relation between FVC and profusion score when pleural thickening was absent ;
(d) less frequent pleural fibrosis (36% v 75%) ;
and (e) less frequent restrictive impairment (23% v 33%). (...)
Mots-clés Pascal : Amiante, Exposition professionnelle, Toxicité, Fibrose, Cellule interstitielle, Fonction respiratoire, Spirométrie, Homme, Classification, Médecine travail, Relation dose réponse, Radiographie, Activité professionnelle
Mots-clés Pascal anglais : Asbestos, Occupational exposure, Toxicity, Fibrosis, Interstitial cell, Lung function, Spirometry, Human, Classification, Occupational medicine, Dose activity relation, Radiography, Professional activity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0126369
Code Inist : 002B03L03. Création : 21/05/1997.