Retention of asbestos fibres in lungs of workers with asbestosis, asbestosis and lung cancer, and mesothelioma in asbestos township.
To conduct a mineralogical study on the particles retained in the necropsied lungs of a homogenous group of asbestos miners and millers from Asbestos township (and a local reference population) and to consider the hypothesis that there is a difference in size between fibres retained in the lungs of patients with asbestosis with and without lung cancer.
Methods-Samples of lung tissue were obtained from 38 patients with asbestosis without lung cancer, 25 with asbestosis and lung cancer, and 12 with mesothelioma, from necropsied Quebec chrysotile miners and millers from Asbestos township.
Fibre concentrations in the lungs of these patients were compared with those in tissue from necropsies carried out on a local reference population : men who had died of either accidental death or acute myocardial infarction between 1990 and 1992. 23 were born before 1940 and 26 after 1940.
Geometric mean (GM) concentrations were higher in cases than in the controls for chrysotile fibres 5 to 10 mum long in patients with asbestosis with or without lung cancer ; for tremolite fibres 5 to 10 mum long in all patients ; for crocidolite, talc, or anthophyllite fibres 5 to 10 mum long in patients with mesothelioma ; for chrysotile and tremolite fibres = 10 mum long in patients with asbestosis ; and crocidolite, talc, or anthophyllite fibres = 10 mum long in patients with mesothelioma. (...)
Mots-clés Pascal : Asbestose, Tumeur maligne, Bronchopulmonaire, Mésothéliome, Exposition professionnelle, Homme, Toxicité, Fibre amiante, Taille, Accumulation biologique, Poumon, Médecine travail, Analyse minéralogique, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie, Bronche pathologie, Tumeur
Mots-clés Pascal anglais : Asbestosis, Malignant tumor, Bronchopulmonary, Mesothelioma, Occupational exposure, Human, Toxicity, Asbestos fiber, Size, Biological accumulation, Lung, Occupational medicine, Mineralogical analysis, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease, Bronchus disease, Tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0126368
Code Inist : 002B03L03. Création : 21/05/1997.