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  1. Self-reported exposure to neurotoxic chemical combinations in the Gulf War : A cross-sectional epidemiologic study.

    Article - En anglais

    Objective

    - To identify risk factors of factor analysis-derived Gulf War-related syndromes.

    Design

    - A cross-sectional survey.

    Participants

    - A total of 249 Gulf War veterans from the Twenty-fourth Reserve Naval Mobile Construction Battalion.

    Data Collection

    - Participants completed standardized booklets measuring self-reported wartime exposures and present symptoms.

    Main Outcome Measures

    - Associations of factor analysis-derived syndromes with risk factors for chemical interactions that inhibit butyrylcholinesterase and neuropathy target esterase.

    Results

    - Risk of syndrome 1 ( « impaired cognition ») was greater in veterans who reported wearing flea collars during the war (5 of 20,25%) than in those who never wore them (7 of 229,3% ; relative risk [RR], 8.7 ; 95% confidence interval [Cl], 3.0-24.7 ; P<. 001).

    Risk of syndrome 2 ( « confusion-ataxia ») increased with a scale of advanced adverse effects from pyridostigmine bromide (X2 for trend, P<. 001), was greater among veterans who believed they had been involved in chemical weapons exposure (18 of 108,17%) than in those who did not (3 of 141,2% ; RR, 7.8 ; 95% Cl, 2.3-25.9 ; P<. 001), and was increased in veterans who had been in a sector of far northeastern Saudi Arabia on the fourth day of the air war (6 of 21,29%) than in those who had not been (15 of 228,7% ; RR, 4.3 ; 95% Cl, 1.9-10.0 ; P=004). (...)

    Mots-clés Pascal : Golfe Persique, Guerre, Degré exposition, Concentration chimique, Neurotoxine, Dépistage, Pharmacocinétique, Ancien combattant, Etude transversale, Facteur risque, Effet secondaire, Homme, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Compte rendu, Soi

    Mots-clés Pascal anglais : Persian Gulf, War, Degree of exposure, Chemical concentration, Neurotoxin, Medical screening, Pharmacokinetics, Veteran, Cross sectional study, Risk factor, Secondary effect, Human, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Report, Self

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0126362

    Code Inist : 002B18F01. Création : 21/05/1997.