Two hundred seven vitamin A-deficient southern Indian children aged 1-7 y (mean age : 56.9 mo) underwent testing of dark-adapted visual and pupillary thresholds in their village setting according to a previously reported protocol.
One hundred thirty (62.8%) of the children also underwent serum retinol testing, and 178 (86.0%) participated in a randomized, placebo-controlled vitamin A dosing trial with pre-and postdose testing of dark-adaptation threshold.
Most subjects (184 of 207,88.9%) were able to complete pupillary testing, an objective sign requiring minimal cooperation, including a high proportion of the youngest children (72.2% of subjects aged 2 y).
The proportion of children completing visual threshold testing, which requires greater understanding and cooperation, was significantly smaller than that able to complete pupillary testing (131 of 207,63.3% ; P<0.0001, chi square).
At baseline (predosing), the mean serum retinol concentration declined in linear fashion with a higher pupillary threshold (0.73 mumol/L with a score ¾ 4 ; 0.47 mumol/L with a score = 8 ; P<0.01).
The mean pupillary threshold for these highly vitamin A-deficient Indian children (-0.622 log cd/m2) was significantly higher than that for 136 more moderately deficient Indonesian children (-0.985 log cd/m2 ; P<0.001, two-sample t test) and 56 normal American children (-1.335 log cd/m2 ; P<0.0001, two-sample t test). (...)
Mots-clés Pascal : Age préscolaire, Rétinol, Etat nutritionnel, Vision scotopique, Réflexe pupillaire, Indice, Surveillance sanitaire, Carence vitaminique, Dépistage, Vitamine, Antioxydant, Epidémiologie, Vision, Trouble nutrition, Inde, Asie, Enfant, Homme
Mots-clés Pascal anglais : Preschool age, Retinol, Nutritional status, Scotopic vision, Pupillary reflex, Index, Sanitary surveillance, Vitamin deficiency, Medical screening, Vitamin, Antioxidant, Epidemiology, Vision, Nutrition disorder, India, Asia, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0123903
Code Inist : 002B29B. Création : 21/05/1997.