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  1. Fulltext. Pupillary threshold as an index of population vitamin A status among children in India.

    Article - En anglais


    Two hundred seven vitamin A-deficient southern Indian children aged 1-7 y (mean age : 56.9 mo) underwent testing of dark-adapted visual and pupillary thresholds in their village setting according to a previously reported protocol.

    One hundred thirty (62.8%) of the children also underwent serum retinol testing, and 178 (86.0%) participated in a randomized, placebo-controlled vitamin A dosing trial with pre-and postdose testing of dark-adaptation threshold.

    Most subjects (184 of 207,88.9%) were able to complete pupillary testing, an objective sign requiring minimal cooperation, including a high proportion of the youngest children (72.2% of subjects aged 2 y).

    The proportion of children completing visual threshold testing, which requires greater understanding and cooperation, was significantly smaller than that able to complete pupillary testing (131 of 207,63.3% ; P<0.0001, chi square).

    At baseline (predosing), the mean serum retinol concentration declined in linear fashion with a higher pupillary threshold (0.73 mumol/L with a score ¾ 4 ; 0.47 mumol/L with a score = 8 ; P<0.01).

    The mean pupillary threshold for these highly vitamin A-deficient Indian children (-0.622 log cd/m2) was significantly higher than that for 136 more moderately deficient Indonesian children (-0.985 log cd/m2 ; P<0.001, two-sample t test) and 56 normal American children (-1.335 log cd/m2 ; P<0.0001, two-sample t test). (...)

    Mots-clés Pascal : Age préscolaire, Rétinol, Etat nutritionnel, Vision scotopique, Réflexe pupillaire, Indice, Surveillance sanitaire, Carence vitaminique, Dépistage, Vitamine, Antioxydant, Epidémiologie, Vision, Trouble nutrition, Inde, Asie, Enfant, Homme

    Mots-clés Pascal anglais : Preschool age, Retinol, Nutritional status, Scotopic vision, Pupillary reflex, Index, Sanitary surveillance, Vitamin deficiency, Medical screening, Vitamin, Antioxidant, Epidemiology, Vision, Nutrition disorder, India, Asia, Child, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0123903

    Code Inist : 002B29B. Création : 21/05/1997.