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  1. Epidemiology of Whipple's disease in Germany : Analysis of 110 patients diagnosed in 1965-95.

    Article - En anglais

    Background 

    The epidemiology of Whipple's disease (WD) is obscure.

    To obtain basic data, we performed an evaluation of WD patients in Germany.

    Methods 

    Information was collected from 110 WD patients diagnosed during 1965-95 at 5 institutions in different regions of Germany.

    Four items were evaluated : 1) year in which the diagnosis was made ; 2) residence and 3) age at the time of diagnosis ; and 4) sex.

    Results 

    WD patients originated from all parts of Germany.

    The incidence of new cases was relatively stable, with a mean of one to two cases per year per collecting centre.

    In 1995, a maximum of 13 new WD patients was diagnosed.

    There was a significant increase in the mean age of patients (1965-75,48.7 years ; confidence interval, ± 3.98 years ; 1976-85,50.7 years, ± 3.69 years ; 1986-95,57.0 years, ± 2.80 years ; P<0.01) and an increasing proportion of women (1965-85,4% ; 1986-1995,22%). Conclusions : Whipple's disease is not quite as rare as commonly assumed.

    There is no obvious geographic predominance.

    During the past three decades, the demography of WD patients has changed.

    Mots-clés Pascal : Lipodystrophie intestinale, Bactériose, Infection, Actinomyces, Actinomycetaceae, Actinomycetales, Actinomycetes, Bactérie, Incidence, Diagnostic, Exploration cytologique, Epidémiologie, Homme, Allemagne, Europe, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale

    Mots-clés Pascal anglais : Whipple disease, Bacteriosis, Infection, Actinomyces, Actinomycetaceae, Actinomycetales, Actinomycetes, Bacteria, Incidence, Diagnosis, Cytologic investigation, Epidemiology, Human, Germany, Europe, Digestive diseases, Intestinal disease, Intestinal malabsorption

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0122211

    Code Inist : 002B13B03. Création : 21/05/1997.